Introduction: The Japanese Joint Committee of Lung Cancer Registry performed the fourth nationwide registry study of surgical cases. Demographics, safety and quality, prognostic information, and correlations between the seventh and the eighth editions of the TNM classification were investigated. The principal results were compared with those of previous Japanese Joint Committee of Lung Cancer Registry studies. Methods: The clinicopathologic profiles, staging, and prognosis of patients who had an operation for primary lung cancer in 2010 were retrospectively collected in 2016 and analyzed. Results: The cohort consisted of 18,973 patients from 297 hospitals (11,771 males, mean age 68.3 years). Tumor smaller than 2.0 cm was seen in 39.0% of patients, and limited resection was performed in 22.7%. The 30‐ and 90‐day mortality rates were 0.43 and 1.26%, respectively. The overall and disease‐free survival rates at 5 years were 74.7 and 67.8%, respectively. The respective 5‐year survival rates by pathological stage in the seventh edition in the present study (2010) and in the previous study (2004) were 88.9% and 86.8% for stage IA, 76.7% and 73.9% for stage IB, 64.1% and 61.6% for stage IIA, 56.1% and 49.8% for stage IIB, 47.9% and 40.9% for stage IIIA, 30.2% and 27.8% for stage IIIB, and 36.1% and 27.9% for stage IV. The 5‐year survival rates by clinical stage in the eighth edition in the present study were 97.0% for stage 0, 91.6% for stage IA1, 81.4% for stage IA2, 74.8% for stage IA3, 71.5% for stage IB, 60.2% for stage IIA, 58.1% for stage IIB, 50.6% for stage IIIA, 40.5% for stage IIIB, 37.5% for stage IIIC, and 36.0% for IVA/B. With restaging, the overall survival rates of clinical stage IA and IB in the seventh edition were stratified into stages 0 to IA3 and stages IA1 to IIA in the eighth edition, respectively. Conclusions: This study demonstrates improved surgical results for lung cancer in Japan. The TNM revision for the eighth edition was supported by the assessment of stage migration from the previous edition and the prognostic stratification.

中文翻译：

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2010 年日本肺癌注册联合委员会数据库 18,973 例手术病例中 TNM 分类第七版和第八版的人口统计学、安全性和质量以及预后信息

介绍：日本肺癌登记联合委员会进行了第四次全国范围的手术病例登记研究。调查了人口统计学、安全性和质量、预后信息以及 TNM 分类第七版和第八版之间的相关性。主要结果与之前日本肺癌登记联合委员会研究的结果进行了比较。方法：回顾性收集2016年2010年原发性肺癌手术患者的临床病理资料、分期及预后情况并进行分析。结果：该队列包括来自 297 家医院的 18,973 名患者（11,771 名男性，平均年龄 68.3 岁）。39.0% 的患者出现小于 2.0 cm 的肿瘤，22.7% 的患者进行了有限切除。30 天和 90 天死亡率分别为 0.43% 和 1.26%，分别。5 年总生存率和无病生存率分别为 74.7% 和 67.8%。本研究第七版（2010 年）和之前研究（2004 年）的病理分期 5 年生存率分别为 IA 期 88.9% 和 86.8%，IB 期 76.7% 和 73.9%，64.1% IIA 期为 61.6%，IIB 期为 56.1% 和 49.8%，IIIA 期为 47.9% 和 40.9%，IIIB 期为 30.2% 和 27.8%，IV 期为 36.1% 和 27.9%。本研究第八版临床分期5年生存率为0期97.0%、IA1期91.6%、IA2期81.4%、IA3期74.8%、IB期71.5%、60.2% IIA 期为 58.1%，IIB 期为 50.6%，IIIA 期为 50.6%，IIIB 期为 40.5%，IIIC 期为 37.5%，IVA/B 期为 36.0%。随着重新分期，第七版临床分期IA和IB的总生存率分别分层为0～IA3期和第八版IA1～IIA期。结论：本研究表明日本肺癌的手术效果有所改善。第八版的 TNM 修订版得到了上一版分期迁移和预后分层评估的支持。