In this paper we present the first example of a lysosome-targeting fluorescent ionophore. Specifically, we synthesized a squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found that it was able to target and efficiently deacidify lysosomes. In contrast, an analogue without a morpholinyl group exhibits much lower ability to localize in lysosomes and is much less active in regulating the lysosomal pH.

中文翻译：

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基于香豆素和方胺的溶酶体靶向荧光离子载体的合成与性能

在本文中，我们提出了靶向溶酶体的荧光离子载体的第一个例子。具体而言，我们合成了带有香豆素荧光团和吗啉基的方酰胺衍生物，发现它能够靶向并有效地使溶酶体脱酸。相反，没有吗啉基的类似物在溶酶体中的定位能力要低得多，并且在调节溶酶体pH方面的活性要差得多。