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Metal-free photocatalytic thiol–ene/thiol–yne reactions
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2018-10-10 , DOI: 10.1039/c8ob02313a
Sarbjeet Kaur 1, 2, 3, 4, 5 , Gaoyuan Zhao 1, 2, 3, 4, 5 , Evan Busch 1, 2, 3, 4, 5 , Ting Wang 1, 2, 3, 4, 5
Affiliation  

The organic photocatalyst (9-mesityl-10-methylacridinum tetrafluoroborate) in the presence of visible light is used to initiate thiol–ene and thiol–yne reactions. Thiyl radicals are generated upon quenching the photoexcited catalyst with a range of thiols. The highlighted mild nature of the reaction conditions allows a broad substrate scope of the reactants. Relying on this efficient metal-free condition, both thiol–ene and thiol–yne reactions between carbohydrates and peptides could be realized in excellent yields.

中文翻译:

无金属的光催化硫醇-烯/硫醇-炔反应

在可见光的存在下,使用有机光催化剂(9-甲磺酰-10-甲基ac啶四氟硼酸酯)引发硫醇-烯和硫醇-炔反应。通过用一定范围的硫醇淬灭光激发的催化剂后会生成巯基。反应条件突出的温和性质允许反应物的广泛的底物范围。依靠这种有效的无金属条件,碳水化合物和多肽之间的硫醇-烯和硫醇-炔反应都可以实现极高的收率。
更新日期:2019-02-14
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