Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water,Organic & Biomolecular Chemistry

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Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2018-10-10 , DOI: 10.1039/c8ob02172d
Fang Ke _{1,

2,

3,

4} , Peng Zhang _{1,

2,

3,

4} , Chen Lin _{1,

2,

3,

4} , Xiaoyan Lin _{1,

2,

3,

4} , Jianhua Xu _{1,

2,

3,

4} , Xiangge Zhou _{4,

5,

6,

7,

8}

Affiliation

An efficient copper-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles with 1,10-phenanthroline as the ligand has been developed. A variety of substituted benzimidazole derivatives can be obtained in yields up to 95%.

中文翻译：