Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected systems have been described, the immune system has been comparatively neglected, despite its pervasive role in the body and the trend towards newer therapeutic products (i.e., complex biologics, nanoparticles, immune checkpoint inhibitors, and engineered T cells) that often cause, or are based on, immune reactions. In this review, we recapitulate some distinctive features of the immune system before reviewing microfluidic devices that mimic lymphoid organs or other organs and/or tissues with an integrated immune system component.

中文翻译：

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致力于开发人类免疫系统芯片平台。

器官芯片（OoC）平台可能会彻底改变药物发现，并可能最终成为精准治疗的重要工具。尽管已经描述了许多单器官和相互关联的系统，但免疫系统相对被忽视了，尽管它在体内发挥着普遍作用，并且有更新的治疗产品（即复杂的生物制品、纳米颗粒、免疫检查点抑制剂和工程化 T 细胞）的趋势）通常会引起或基于免疫反应。在这篇综述中，我们在回顾具有集成免疫系统组件的模仿淋巴器官或其他器官和/或组织的微流体装置之前，概述了免疫系统的一些独特特征。