Although retrograde approach has greatly improved the success rate of percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO), retrograde wire externalization still remains challenging and time-consuming in some cases. Cases utilizing “Active Greeting Technique (AGT)”, a mother-and-child catheter based technique to facilitate retrograde wire externalization, were extracted from Chronic Total Occlusion Club, China (CTOCC) database. AGT was performed by deep intubation a mother-and-child catheter (Guidezilla™ extension, 4 or 5 Fr inner catheter, and etc.) in combination with either reverse controlled antegrade or retrograde subintimal tracking (CART) technique or retrograde wire crossing technique. A total of 111 patients with 112 CTO lesions treated with this technique were retrospectively analyzed. Reverse CART technique and retrograde wire crossing technique were performed in 90.2% and 9.8% of all procedures. The utilization of Guidezilla™ extension, 4 Fr, and 5 Fr inner catheter accounted for 94.6%, 3.6%, and 1.8%, respectively. Externalization of retrograde wire was successful in all cases. No procedural complications were adjudicated to AGT. Complications independent of AGT included two target vessel perforations and two collateral perforations. No in-hospital major adverse cardiac events were found. AGT is a feasible and safe technique that facilitates retrograde wire externalization.