An efficient and direct C(sp³)-H functionalization of 2-methyl azaarenes with persistent nitroxide radical 4-substituted-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) under neutral conditions has been developed. A broad of 2-methylazaarenes could be reacted with 4-substituted TEMPOs to afford corresponding azaarene 2-methoxylamines by using cheaper copper (II) acetate hydrate as oxidant.

中文翻译：

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使用4-取代的TEMPO对2-甲基氮杂芳烃进行直接C（sp ³）-H官能化

已经开发了在中性条件下具有持久性硝基氧化物自由基4-取代的2,2,6,6-四甲基哌啶-N-氧基（TEMPO）的有效的，直接的C（sp ³）-H功能化的2-甲基氮杂芳烃。通过使用便宜的乙酸铜（II）水合物作为氧化剂，可使广泛的2-甲基氮杂芳烃与4-取代的TEMPO反应，得到相应的氮杂芳烃2-甲氧基胺。