The bioactive constituents in ginger extract are responsible for anti‐hyperglycemic effects and the underlying mechanisms are incompletely understood. Gingerenone A (Gin A) has been identified as an inhibitor of p70 S6 (S6K1), a kinase that plays a critical role in the pathogenesis of insulin resistance. This study aims to evaluate if Gin A can sensitize the insulin receptor by inhibiting S6K1 activity.

中文翻译：

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姜黄酮A通过抑制p70 S6激酶的活性来刺激胰岛素受体并增加葡萄糖摄取。

姜提取物中的生物活性成分负责抗高血糖作用，其潜在机理尚不完全清楚。生姜酮A（Gin A）已被鉴定为p70 S6（S6K1）的抑制剂，该激酶在胰岛素抵抗的发病机理中起着至关重要的作用。这项研究旨在评估Gin A是否可以通过抑制S6K1活性来敏化胰岛素受体。