The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.

中文翻译：

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化学方法，以增强基于5-氨基乙酰丙酸的光动力疗法和光诊断

施用5-氨基乙酰丙酸（ALA）以产生增强的细胞内水平的内源性卟啉是目前用于光动力疗法（PDT）和光诊断（PDD）的最重要方法之一。尽管基于ALA的PDT前景广阔，但是ALA的物理化学行为和化学反应性仍然存在问题，并且已经采取了多种化学方法来改善细胞递送，增强卟啉的产生并产生对ALA具有适当稳定性的ALA前药。方便的临床使用，以及对癌组织的选择性。尽管取得了相当大的成功，但仍然需要解决许多挑战，并通过在该领域应用化学见解来开发机会。