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The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort
Environment International ( IF 11.8 ) Pub Date : 2018-10-06 , DOI: 10.1016/j.envint.2018.09.049
Clara G Sears 1 , Joseph M Braun 2 , Patrick H Ryan 3 , Yingying Xu 4 , Erika F Werner 5 , Bruce P Lanphear 6 , Gregory A Wellenius 2
Affiliation  

Traffic-related air and noise pollution may increase the risk for cardiovascular disorders, especially among susceptible populations like pregnant women. The objective of this study was to evaluate the association of exposure to traffic-related air pollution and traffic noise with blood pressure in pregnant women. We extracted systolic blood pressure (SBP) and diastolic blood pressure (DBP) at ≥20 weeks gestation, as well as hypertensive disorders of pregnancy from medical records in the HOME Study, a prospective pregnancy and birth cohort from Cincinnati, OH (n = 370). We estimated exposure to elemental carbon attributable to traffic (ECAT),1 a marker of traffic-related air pollution, at women's residences at ~20 weeks gestation using a validated land use regression model and traffic noise using a publicly available transportation noise model. We used linear mixed models and modified Poisson regression adjusted for covariates to examine associations of ECAT and traffic noise with blood pressure and hypertensive disorders of pregnancy risk, respectively. In adjusted models, we found a 1.6 (95% CI = 0.02, 3.3; p = 0.048) mm Hg increase in SBP associated with an interquartile range increase in ECAT concentration; the association was stronger after adjusting for traffic noise (1.9 mm Hg, 95% = 0.1, 3.7; p = 0.035). ECAT concentrations were not significantly associated with DBP or hypertensive disorders of pregnancy, and traffic noise was not associated with SBP, DBP, or hypertensive disorders of pregnancy. There was no evidence of a joint effect of traffic noise and ECAT on any outcome. In this cohort, higher residential traffic-related air pollution exposure at ~20 weeks gestation was associated with higher SBP in late pregnancy. It is important for future studies of traffic-related air or noise pollution to jointly consider both exposures and neighborhood characteristics given their correlation and potential cumulative impact on cardiovascular health.



中文翻译:

HOME 研究队列中与交通相关的空气和噪音污染与母亲血压和妊娠期高血压疾病的关系

与交通相关的空气和噪音污染可能会增加患心血管疾病的风险,尤其是孕妇等易感人群。本研究的目的是评估孕妇暴露于交通相关空气污染和交通噪音与血压之间的关系。我们从 HOME 研究的医疗记录中提取了妊娠 ≥20 周时的收缩压 (SBP) 和舒张压 (DBP),以及妊娠期高血压疾病,该研究是来自俄亥俄州辛辛那提的前瞻性妊娠和出生队列(n = 370) )。我们使用经过验证的土地利用回归模型估算了妊娠约 20 周女性住所的交通元素碳暴露量 (ECAT) 1,这是与交通相关的空气污染的标志,并使用公开的交通噪声模型估算了交通噪声我们使用线性混合模型和针对协变量调整的修正泊松回归来检查 ECAT 和交通噪音分别与血压和妊娠高血压疾病风险的关联。在调整后的模型中,我们发现 SBP 增加 1.6(95% CI = 0.02, 3.3;p = 0.048)mm Hg,与 ECAT 浓度四分位数范围增加相关;调整交通噪音后,这种关联性更强(1.9 mm Hg,95% = 0.1, 3.7;p = 0.035)。ECAT浓度与舒张压或妊娠期高血压疾病没有显着相关性,交通噪音与收缩压、舒张压或妊娠期高血压疾病也没有显着相关性。没有证据表明交通噪音和 ECAT 对任何结果有共同影响。在该队列中,妊娠约 20 周时较高的住宅交通相关空气污染暴露与妊娠后期较高的收缩压相关。鉴于它们的相关性和对心血管健康的潜在累积影响,未来与交通相关的空气或噪音污染的研究必须共同考虑暴露和邻里特征。

更新日期:2018-10-08
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