Lupus nephritis (LN) is a common and devastating complication caused by systemic lupus erythematosus. In this study, we evaluated the expression and mechanism of Fos-related antigen 2 (Fra-2) in LN. The results showed that Fra-2 was significantly increased in kidney biopsies of LN patients compared with healthy controls and other kidney disease in glomerular podocytes. The MRL/lpr mouse strain is a murine model of lupus, and it was used to study the mechanisms of Fra-2 in LN. The results showed that Fra-2 was expressed in the glomerular podocytes. We investigated the effects of inflammatory stimuli on Fra-2 protein expression in the glomerular podocytes, and found that interferon gamma was most effective at increasing Fra-2 protein expression. Knockdown of Fra-2 using siRNA enhanced the protein expression of nephrin. Therefore, Fra-2 may be a specific drug target for podocyte injury in LN.

狼疮性肾炎（LN）是由系统性红斑狼疮引起的常见破坏性并发症。在这项研究中，我们评估了Fos相关抗原2（Fra-2）在LN中的表达及其机制。结果表明，与健康对照和其他肾病肾小球足细胞相比，LN患者的肾脏活检中的Fra-2显着增加。MRL / lpr小鼠品系是狼疮的小鼠模型，用于研究LN中Fra-2的机制。结果表明，Fra-2在肾小球足细胞中表达。我们调查了炎性刺激对肾小球足细胞中Fra-2蛋白表达的影响，发现干扰素γ最有效地增加了Fra-2蛋白表达。使用siRNA敲除Fra-2可增强nephrin的蛋白表达。所以，