Morphological change that includes diffuse effacement of podocyte foot processes is correlated with proteinuria in patients with lupus nephritis (LN). We collected the data of clinico-pathological parameters and assessed foot process width (FPW) as an index of podocyte effacement in 73 patients with LN who had undergone renal biopsy. The multivariate analysis revealed that female gender (OR: 5.288; 95%CI: 1.197–37.29; p = .0267) and FPW (OR = 0.999, 95%CI = 0.997–0.999, p = .0150) were significantly predictive of a complete renal response (CR) at 6 months, while lymphocyte counts (OR = 1.002; 95%CI = 1.001–1.003, p = .0028) and FPW (OR = 0.998, 95%CI = 0.996–0.999, p = .0027) were significantly predictive of CR at 12 months. The cut-off point determined by the Classification and Regression Trees algorithm showed that FPW <908.3 nm provides the best performance for predicting patients who achieve CR at 12 months. A smaller FPW appears to be a predictive factor for CR at 6 and 12 months after induction therapy.

狼疮性肾炎（LN）患者的形态变化（包括足细胞足突的弥漫性消失）与蛋白尿相关。我们收集了临床病理参数的数据并评估了足突宽度（FPW），作为73例接受肾活检的LN患者足细胞消失的指数。多元分析显示，女性（OR：5.288； 95％CI：1.197–37.29；p  = .0267）和FPW（OR = 0.999，95％CI = 0.997–0.999，p  = .0150）显着预测了在6个月时完全肾反应（CR），而淋巴细胞计数（OR = 1.002; 95％CI = 1.001–1.003，p  = .0028 ）和FPW（OR = 0.998，95％CI = 0.996–0.999，p = .0027）可以显着预测12个月时的CR。通过分类树和回归树算法确定的临界点表明，<908.3 nm的FPW为预测12个月后达到CR的患者提供了最佳性能。FPW较小似乎是诱导治疗后6个月和12个月时CR的预测因素。