Antimicrobial photodynamic therapy (aPDT) is an effective way to combat infectious diseases and antibiotic resistance. Photosensitizer is a key factor of aPDT and has triggered extensive research interest. In this study, a new asymmetric Zn(II) phthalocyanine mono-substituted with a triazatricyclodecane moiety (compound 3) and its cationic N-methylated derivative (compound 4) were synthesized. Their photodynamic antimicrobial activities were evaluated using bioluminescent bacterial strains. Compound 3 showed phototoxicity only toward the Gram-positive bacteria, whereas the cationic derivative compound 4 exhibited strong anti-bacterial activity against both Gram-positive and Gram-negative strains. These bacterial species were eradicated (>4.0 logs or 99.99% killing) at appropriate concentrations of compound 4 with 12.7 J/cm² of red light, demonstrating compound 4 as a potent aPDT agent.

抗菌素光动力疗法（aPDT）是对抗传染病和抗生素耐药性的有效方法。光敏剂是aPDT的关键因素，并引起了广泛的研究兴趣。在这项研究中，合成了三氮杂三环癸烷部分（化合物3）单取代的新型不对称Zn（II）酞菁及其阳离子N-甲基化衍生物（化合物4）。使用生物发光细菌菌株评估了它们的光动力学抗菌活性。化合物3仅对革兰氏阳性细菌显示光毒性，而阳离子衍生物化合物4对革兰氏阳性和革兰氏阴性菌株均表现出强大的抗菌活性。这些化合物在适当浓度的化合物4和12.7 J / cm ²的红光下被消灭（> 4.0 log或99.99％的杀灭率），证明化合物4为有效的aPDT试剂。