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Copper-catalyzed synthesis of 1,3,5-triaryl-4-(organylselanyl)-1H-pyrazoles by one-pot multicomponent reactions
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2018-10-06 , DOI: 10.1016/j.tetlet.2018.10.008
Thalita F.B. de Aquino , Jessica P. Seidel , Daniela H. de Oliveira , José Edmilson R. do Nascimento , Diego Alves , Gelson Perin , Eder J. Lenardão , Ricardo F. Schumacher , Raquel G. Jacob

We describe herein our results for the multicomponent synthesis of 1,3,5-triaryl-4-(organylselanyl)pyrazoles by copper-catalyzed cyclocondensation and a direct CH bond selenation reaction of arylhydrazines, chalcones and diorganyl diselenides using catalytic amount of CuBr in acetic acid as solvent at reflux temperature. This methodology proved to be simple and efficient to furnish a range of 4-(organylselanyl)-1H-pyrazoles in moderate to good yields.



中文翻译:

一锅多组分反应铜催化合成1,3,5-三芳基-4-(有机基硒基)-1 H-吡唑

我们在本文中描述了通过铜催化的环缩合反应以及使用催化量的CuBr在芳基肼,查耳酮和二有机基二硒代烃中直接进行C H键硒化反应的多组分合成1,3,5-三芳基-4-(有机基硒基)吡唑的结果。在回流温度下用乙酸作为溶剂。事实证明,该方法简单,有效,可以以中等至良好的产率提供一系列4-(有机基硒基)-1 H-吡唑。

更新日期:2018-10-06
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