Flaviviruses possess a conserved protease that is vital for viral maturation. We have designed catalytic metallopeptides for inactivation of both Zika and West Nile viral proteases, and potentially other viral homologues, by irreversible target destruction and low off-target activity against host proteases. Oxidative damage promoted by metallopeptides was characterized by mass spectrometry, localized to specific active site residues, and correlated with catalyst activity.

中文翻译：

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寨卡病毒和西尼罗河病毒NS2B / NS3蛋白酶的广谱催化金属肽灭活剂†

黄病毒具有保守的蛋白酶，这对于病毒的成熟至关重要。我们已经设计了催化金属肽，通过不可逆的靶标破坏和针对宿主蛋白酶的低脱靶活性，使Zika和West Nile病毒蛋白酶以及潜在的其他病毒同源物失活。金属肽促进的氧化损伤通过质谱表征，定位于特定的活性位点残基，并与催化剂活性相关。