Polydopamine is a versatile and organic material that can be deposited as a conformal film with nanometer thickness on virtually any substrate. Much of the initial foundational work regarding polydopamine synthesis and processing was reported during the 2000s. Latter years have witnessed increasing interest and widespread adoption of polydopamine as a material for many applications including medicine. Conformal polydopamine coatings confer unique chemical and physical properties to many substrate materials including metals, ceramics, polymers, and beyond. Polydopamine-modified surfaces permit facile bioconjugation of many biological materials for potential use as bioadhesives, contrast agents, drug delivery systems, and protein-adsorption resistant interfaces. Polydopamine-based materials and interfaces may improve the performance of biomedical devices used in neurotechnology, diagnostics, and cardiovascular applications. This highlight article reviews recent advances in polydopamine processing capabilities. The use of polydopamine as a material in various biomedical applications is also discussed. Finally, challenges and opportunities in translating biomedical technologies featuring polydopamine are summarized.

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聚多巴胺纳米结构作为医学应用的生物材料

聚多巴胺是一种通用的有机材料，几乎可以在任何基材上沉积成具有纳米厚度的保形膜。关于聚多巴胺合成和加工的许多初期基础工作在2000年代期间都有报道。近几年来，人们对聚多巴胺作为包括医学在内的许多应用的材料越来越感兴趣并被广泛采用。保形聚多巴胺涂料为许多基材（包括金属，陶瓷，聚合物等）赋予了独特的化学和物理性能。聚多巴胺修饰的表面允许许多生物材料轻松生物缀合，可潜在地用作生物粘合剂，造影剂，药物递送系统和抗蛋白质吸附的界面。基于聚多巴胺的材料和界面可以改善用于神经技术，诊断和心血管应用的生物医学设备的性能。这篇重点文章回顾了聚多巴胺加工能力的最新进展。还讨论了聚多巴胺在各种生物医学应用中作为材料的用途。最后，总结了翻译以聚多巴胺为特色的生物医学技术的挑战和机遇。