The cell microenvironment choreographs the behaviors of cells through multiple well-controlled signals. For basic biological study and cell-based therapies, it is essential to decipher the complicated cell–matrix interactions, and to develop ways to mimic the dynamic microenvironment so that desired biological functions of cells can be guided. For this, biomaterials with the ability to spatiotemporally impart biochemical and biophysical cues to manipulate cell fate have been developed recently. The dynamic property and programmable features of stimuli-responsive biointerfaces endow them with the outstanding ability to develop advanced biological systems. In this review, we illustrate the recent progress of stimuli-responsive biosystems with a particular emphasis on their explorations for cell-based fundamental studies, disease diagnosis and regenerative therapy. Some basic principles and strategies for the design of dynamic platforms are also discussed in this review. Finally, we conclude with an outlook on current challenges and future of dynamic platforms for cell study and biomedical applications. Overall, we anticipate that this review will boost the development of dynamic and multifunctional biosystems by inspiring interest from various disciplines, including chemistry, materials science, cell biology, nanotechnology, biomedical engineering, as well as clinical research.

中文翻译：

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操纵细胞命运：在功能平台上动态控制细胞行为

细胞微环境通过多种控制良好的信号编排了细胞的行为。对于基础生物学研究和基于细胞的疗法，必须破译复杂的细胞-基质相互作用，并开发模拟动态微环境的方法，以便可以指导所需的细胞生物学功能。为此，近来已经开发了具有时空赋予生物化学和生物物理线索以操纵细胞命运的能力的生物材料。刺激响应性生物界面的动态特性和可编程功能使它们具有开发先进生物系统的出色能力。在这篇综述中，我们说明了刺激反应性生物系统的最新进展，特别强调了它们对基于细胞的基础研究的探索，疾病诊断和再生疗法。本文还讨论了动态平台设计的一些基本原理和策略。最后，我们对细胞研究和生物医学应用的动态平台的当前挑战和未来进行了展望。总体而言，我们希望这次审查会激发化学，材料科学，细胞生物学，纳米技术，生物医学工程以及临床研究等各个学科的兴趣，从而促进动态和多功能生物系统的发展。