Background

Personal care product chemicals may be contributing to risk for asthma and other atopic illnesses. The existing literature is conflicting, and many studies do not control for multiple chemical exposures.

Methods

We quantified concentrations of three phthalate metabolites, three parabens, and four other phenols in urine collected twice during pregnancy from 392 women. We measured T helper 1 (Th1) and T helper 2 (Th2) cells in their children's blood at ages two, five, and seven, and assessed probable asthma, aeroallergies, eczema, and lung function at age seven. We conducted linear and logistic regressions, controlling for additional biomarkers measured in this population as selected by Bayesian Model Averaging.

Results

The majority of comparisons showed null associations. Mono-n-butyl phthalate (MnBP) was associated with higher Th2% (RR: 10.40, 95% CI: 3.37, 17.92), and methyl paraben was associated with lower Th1% (RR: −3.35, 95% CI: −6.58, −0.02) and Th2% at borderline significance (RR: −4.45, 95% CI: −8.77, 0.08). Monoethyl phthalate was associated with lower forced expiratory flow from 25 to 75% of forced vital capacity (FEF_25–75%) (RR: −3.22 L/s, 95% CI: −6.02, −0.34). Propyl paraben (OR: 0.86, 95% CI: 0.74, 0.99) was associated with decreased odds of probable asthma.

Conclusions

While some biomarkers, particularly those from low molecular weight phthalates, were associated with an atopic cytokine profile and poorer lung function, no biomarkers were associated with a corresponding increase in atopic disease.

中文翻译：

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CHAMACOS 研究中个人护理产品化学生物标志物的产前母尿浓度与儿童呼吸道和过敏结局之间的关联

背景

个人护理产品化学品可能会增加患哮喘和其他特应性疾病的风险。现有文献相互矛盾，许多研究没有控制多种化学品暴露。

方法

我们对 392 名女性在怀孕期间两次收集的尿液中的三种邻苯二甲酸酯代谢物、三种对羟基苯甲酸酯和四种其他酚类的浓度进行了定量。我们测量了孩子 2 岁、5 岁和 7 岁时血液中的辅助性 T 1 (Th1) 和辅助性 T 2 (Th2) 细胞，并评估了 7 岁时可能的哮喘、空气过敏、湿疹和肺功能。我们进行了线性和逻辑回归，控制了通过贝叶斯模型平均选择的该人群中测量的其他生物标志物。

结果

大多数比较显示无效关联。邻苯二甲酸单正丁酯 (MnBP) 与较高的 Th2% 相关（RR：10.40，95% CI：3.37，17.92），对羟基苯甲酸甲酯与较低的 Th1% 相关（RR：-3.35，95% CI：-6.58） ，-0.02）和 Th2% 处于临界显着性（RR：-4.45，95% CI：-8.77，0.08）。邻苯二甲酸单乙酯与用力肺活量的 25% 至 75% 之间的较低用力呼气流量相关 (FEF _25–75% ) (RR: -3.22 L/s, 95% CI: -6.02, -0.34)。对羟基苯甲酸丙酯（OR：0.86，95% CI：0.74，0.99）与哮喘可能性降低相关。

结论

虽然一些生物标志物，特别是来自低分子量邻苯二甲酸盐的生物标志物，与特应性细胞因子谱和较差的肺功能相关，但没有生物标志物与特应性疾病的相应增加相关。