Coffee is a drink prepared from roasted coffee beans and is lauded for its aroma and flavour. It is the third most popular beverage in the world. This beverage is known by its stimulant effect associated with the presence of methylxanthines. Caffeine, a purine-like molecule (1,3,7 trymetylxantine), is the most important bioactive compound in coffee, among others such as chlorogenic acid (CGA), diterpenes, and trigonelline. CGA is a phenolic acid with biological properties as antioxidant, anti-inflammatory, neuroprotector, hypolipidemic, and hypoglicemic. Purinergic system plays a key role inneuromodulation and homeostasis. Extracellular ATP, other nucleotides and adenosine are signalling molecules that act through their specific receptors, namely purinoceptors, P1 for nucleosides and P2 for nucleotides. They regulate many pathological processes, since adenosine, for instance, can limit the damage caused by ATP in the excitotoxicity from the neuronal cells. The primary purpose of this review is to discuss the effects of coffee, caffeine, and CGA on the purinergic system. This review focuses on the relationship/interplay between coffee, caffeine, CGA, and adenosine, and their effects on ectonucleotidases activities as well as on the modulation of P1 and P2 receptors from central nervous system and also in peripheral tissue.

咖啡是一种由烘焙咖啡豆制成的饮料，因其香气和风味而广受赞誉。它是世界上第三大最受欢迎的饮料。这种饮料因与甲基黄嘌呤的存在有关的刺激作用而为人所知。咖啡因是一种嘌呤样分子（1,3,7色胺基黄嘌呤），是咖啡中最重要的生物活性化合物，其中包括绿原酸（CGA），二萜和Trigonelline。CGA是一种酚酸，具有生物学特性，如抗氧化剂，消炎药，神经保护剂，降血脂药和降血糖药。嘌呤能系统在神经调节和体内平衡中起关键作用。细胞外ATP，其他核苷酸和腺苷是通过其特定受体起作用的信号分子，即嘌呤受体，P1代表核苷，P2代表核苷酸。它们调节许多病理过程，因为例如腺苷可以限制由ATP引起的神经元细胞兴奋性毒性的损害。本文的主要目的是讨论咖啡，咖啡因和CGA对嘌呤能系统的影响。这篇综述着重于咖啡，咖啡因，CGA和腺苷之间的关系/相互作用，以及它们对胞外核苷酸酶活性以及中枢神经系统以及周围组织中P1和P2受体的调节的影响。