In this article, the plantwide control of a novel process for diethyl oxalate production via two steps is investigated. The unique feature of this process is that there is a closed regeneration-coupling circulation. It results in that two steps should be matched properly and mass balance for overall reaction should be satisfied precisely. An effective control structure using a feedforward ratio with composition controller is determined.

Later, safety analysis for this process is investigated by the integration of dynamic simulation and HAZOP (hazard and operability analysis). In comparison with heuristic HAZOP, quantitative deviations can be introduced. Quantitative variation trends and change rates of important variables can be determined. Determining increase rate in temperature and pressure is significantly important, since response time as indirect indictor can be used to assess the possibility of risk. Finally, a general procedure based on simulation for design and safety analysis of chemical process is proposed.

在本文中，研究了通过两个步骤对草酸二乙酯生产新工艺进行全厂控制。该过程的独特之处在于，存在闭合的再生耦合循环。结果是两个步骤应该适当地匹配，并且应该精确地满足整个反应的质量平衡。确定了使用前馈比和成分控制器的有效控制结构。

后来，通过动态模拟和HAZOP（危害和可操作性分析）的集成来研究此过程的安全性分析。与启发式HAZOP相比，可以引入定量偏差。可以确定重要变量的定量变化趋势和变化率。确定温度和压力的增加速率非常重要，因为可以将间接指示器的响应时间用于评估风险的可能性。最后，提出了一种基于仿真的化学过程设计和安全分析的通用程序。