This account focuses on our work in palladium/norbornene-catalyzed selective ortho-arylation and ortho-acylation of aryl halides. It will discuss our synthetic plan, initial design and revised strategy in the enantioselective synthesis of the rhazinal family of natural products. It also shows our efforts on the α-acylation reaction by the cleavage of various C(O)–X bonds, along with some mechanistic studies. 1 Introduction 2 Synthesis of the Rhazinal Family of Natural Products 2.1 Initial Design 2.2 Revised Strategy 2.3 Enantioselective Synthesis of the Rhazinal Family of Natural Products 3 Catalytic ortho-Acylation 3.1 Acid Chloride and Anhydride Strategy 3.2 Cleavage of C(O)–S Bond of Thioesters by Pd, Norbornene and Copper Cocatalysis 4 Decarboxylative Alkynylation 5 Conclusion

中文翻译：

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在钯/降冰片烯催化芳基卤化物的邻位官能化中开发新型亲电试剂

该帐户侧重于我们在钯/降冰片烯催化的芳基卤化物的选择性邻位芳基化和邻位酰化方面的工作。它将讨论我们在天然产物鼠尾素家族的对映选择性合成中的合成计划、初步设计和修订策略。它还显示了我们通过裂解各种 C(O)-X 键以及一些机理研究对 α-酰化反应的努力。1 引言 2 天然产物 Rhazinal 族的合成 2.1 初始设计 2.2 修订策略 2.3 Rhazinal 天然产物族的对映选择性合成 3 催化邻位酰化 3.1 酰氯和酸酐策略 3.2 硫代 C(O)-S 键的裂解通过 Pd、降冰片烯和铜共催化 4 脱羧炔基化 5 结论