当前位置: X-MOL 学术Org. Biomol. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2018-10-03 , DOI: 10.1039/c8ob01955j
Yuji Yamazaki 1, 2, 3, 4, 5 , Yukiko Nambu 6, 7, 8, 9, 10 , Masashi Ohmae 1, 2, 3, 4, 5 , Manabu Sugai 6, 7, 8, 9, 10 , Shunsaku Kimura 1, 2, 3, 4, 5
Affiliation  

Immune responses against Lewis y (LY) displayed on nanocarriers at different surface densities were studied. The high surface density of LY was obtained by the A2B-type amphiphilic polypeptides having LY at the two terminals [LY-poly(sarcosine)2-b-(L- or D-Leu-Aib)6]. The equimolar mixture of these two amphiphilic polypeptides formed interdigitated planar sheet-like molecular assemblies densely displaying LY (G4). G4 seemed to induce the anti-LY IgM upon immunization to BALB/c mice by only a single administration. However, the amount of anti-LY IgM produced was moderate and significantly less than that induced by two administrations of the other molecular assembly (G1) with the average surface density of LY at a 1/4 of that of G4. Further, the anti-LY IgM produced after two administrations of G4 lowered the avidity more than after one administration.

中文翻译:

在自组装纳米载体上密集显示对Lewis Y肿瘤相关碳水化合物抗原的免疫反应

研究了在不同表面密度下纳米载体上对Lewis y(LY)的免疫反应。通过在两个末端具有LY的A 2 B型两亲多肽[LY-poly(sarcosine)2 - b-L-D -Leu-Aib)6获得了LY的高表面密度。]。这两个两亲性多肽的等摩尔混合物形成了相互交叉的平面片状分子组件,密集地显示了LY(G4)。仅通过单次施用,在对BALB / c小鼠免疫后,G4似乎诱导抗LY IgM。然而,产生的抗LY IgM的量是中等的,并且显着少于两次施用另一种分子组件(G1)所诱导的量,其中LY的平均表面密度是G4的1/4。此外,两次给予G4后产生的抗LY IgM比一次给予后降低了亲和力。
更新日期:2018-11-07
down
wechat
bug