Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin. SiNP-ALG-Pt conjugate was more active than both cisplatin and 1, due to its more efficient cell uptake, whereas the SiNP-ALG unplatinated nanoparticles were deprived of any nonspecific toxicity.

带有3-氨基丙基臂（SiNP）的无孔二氧化硅纳米颗粒的外壳进一步用藻酸（SiNP-ALG）修饰，作为Pt抗肿瘤剂的潜在生物相容性传递系统。通过在SiNP-ALG上的侧链羧酸盐基团与SNP的游离氨基基团之间形成酰胺键，将此类颗粒与前药（OC -6-44）-乙酰基（β-丙氨酸）二氨基二氯铂铂（IV）1偶联。复杂的。从肿瘤细胞中提取的细胞溶胶能够快速有效地还原Pt（IV）前药，并产生活性代谢物顺铂。SiNP-ALG-Pt偶联物比顺铂和1都更具活性，由于其更有效的细胞摄取，而SiNP-ALG未镀铂的纳米粒子被剥夺了任何非特异性毒性。