The degradation in vivo and its effect on the supermolecular structure of poly(caprolactone) was examined. Poly(caprolactone) (PCL) samples were prepared in the form of porous scaffolds implanted into rat calvarial defects. The degradation was investigated by means of gel permeation chromatography, wide angle X-ray scattering (WAXS), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The study showed that the observed decrease of PCL crystallinity during degradation is accompanied by reduction of crystal size and/or perfection. The observed phenomenon could be explained by the presence of the high content of the low mobile fraction of investigated polymer, consisting not only almost 50% of crystal fraction but also most probably relatively high fraction of s.c. rigid amorphous fraction (RAF). Considering the type of structure characterized by the dominance of low mobile fraction, it is expected that the degradation will mainly concern these fractions, which in turn will lead to a decrease in the degree of crystallinity as well as crystal size and/or perfection.

体内降解考察了其对聚己内酯超分子结构的影响。聚己内酯（PCL）样品以植入大鼠颅盖缺损的多孔支架的形式制备。通过凝胶渗透色谱法，广角X射线散射（WAXS），扫描电子显微镜（SEM）和差示扫描量热法（DSC）研究降解。研究表明，降解过程中观察到的PCL结晶度降低伴随着晶体尺寸的减小和/或完美度的降低。所观察到的现象可以通过存在高含量的低流动性的研究聚合物来解释，该聚合物不仅包含几乎50％的晶体级分，而且还可能包含较高比例的sc刚性无定形级分（RAF）。