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Bispecific applications of non-immunoglobulin scaffold binders
Methods ( IF 4.8 ) Pub Date : 2019-02-01 , DOI: 10.1016/j.ymeth.2018.09.010
Sophia Hober , Sarah Lindbo , Johan Nilvebrant

Non-immunoglobulin scaffolds represent a proven group of small affinity proteins that can be engineered in vitro to similar affinity and potency as monoclonal antibodies. Several novel candidate biotherapeutics that exploit the potential advantages scaffold proteins hold over larger and more complex antibodies have been developed over the past decade. The ease of using small and robust binding proteins as flexible and modular building blocks has led to the development of a wide range of innovative approaches to combine them in various bi- and multispecific formats. This progress is expected to aid the ongoing challenge of identifying niche applications where clear differentiation from antibody-based molecules will be key to success. Given the many engineering options that are available for non-immunoglobulin scaffold proteins, they have potential to not only complement but probably also surpass antibodies in certain applications.

中文翻译:

非免疫球蛋白支架结合剂的双特异性应用

非免疫球蛋白支架代表了一组经过验证的小亲和蛋白,可以在体外进行工程改造,使其具有与单克隆抗体相似的亲和力和效力。在过去的十年中,已经开发出几种新型候选生物治疗剂,它们利用支架蛋白相对于更大和更复杂的抗体的潜在优势。使用小而坚固的结合蛋白作为灵活和模块化的构建块的便利性导致了广泛的创新方法的发展,以将它们以各种双特异性和多特异性形式结合起来。预计这一进展将有助于确定利基应用的持续挑战,其中与基于抗体的分子的明确区分将是成功的关键。鉴于可用于非免疫球蛋白支架蛋白的许多工程选项,
更新日期:2019-02-01
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