An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF₃ pyridines, through the regioselective, sequential formation of two C–C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.

中文翻译：

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通过可见光诱导的还原性自由基偶联 实现烯烃的无金属分子间碳吡啶基化†

已经描述了一种有效的，无金属的，通过Hantzsch酯和可见光实现的苯乙烯分子间三组分碳吡啶基化的策略。这种多用途的协议可以访问重要的β-CF _3个，而不使用外源性催化剂的吡啶，通过区域选择性，两个C-C键依次形成。通过基于天然产物和药物的复杂分子的功能化，已经证明了这种良性方案的价值。