Microfabricated nanofluidic electrochemical devices offer a highly controlled nanochannel geometry; they confine the volume of chemical reactions to the nanoscale and enable greatly amplified electrochemical detection. Here, the generation of stable light emission by electrochemiluminescence (ECL) in transparent nanofluidic devices is demonstrated for the first time by exploiting nanogap amplification. Through continuous oxidation and reduction of [Ru(bpy)₃]²⁺ luminophores at electrodes positioned at opposite walls of a 100 nm nanochannel, we compare classic redox cycling and ECL annihilation. Enhanced ECL light emission of attomole luminophore quantities is evidenced under ambient conditions due to the spatial confinement in a 10 femtoliter volume, resulting in a short diffusion timescale and highly efficient ECL reaction pathways at the nanoscale.

中文翻译：

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通过纳米流体限制增强的hil灭电化学发光†

超细加工的纳米流体电化学装置可提供高度可控的纳米通道几何形状。它们将化学反应的范围限制在纳米范围内，并能够大大放大电化学检测的范围。在这里，通过利用纳米间隙扩增首次证明了在透明纳米流体装置中通过电化学发光（ECL）产生稳定的发光。通过连续氧化和还原[Ru（bpy）₃ ] ²⁺在位于100 nm纳米通道相对壁处的电极上的发光体，我们比较了经典的氧化还原循环和ECL ation灭。在环境条件下，由于空间限制在10飞升的体积内，从而证明了原子发光体量的增强的ECL发光增强，从而导致了较短的扩散时间尺度和纳米级的高效ECL反应途径。