Background

Evidence establishing a link between acne vulgaris (AV) and hidradenitis suppurativa (HS) is limited, and the burden of AV in adults with HS is unknown.

Objective

To determine the prevalence of AV among adults with HS and determine the strength of this association.

Methods

Cross-sectional analysis identifying adults with AV among patients with and without HS by using electronic health record data from a population-based sample of more than 55 million patients.

Results

The prevalence of AV among adults with HS was 15.2% (7315 of 48,085) compared with 2.9% (497,360 of 16,899,470) for adults without HS (P < .001). The prevalence was greatest among patients with HS who were female (5870 of 35,790 [16.4%]), were 18 to 44 years old (5260 of 28,870 [18.2%]), were nonwhite (3120 of 17,825 [17.5%]), were obese (5430 of 35,135 [15.5%]), and had polycystic ovarian syndrome (685 of 2385 [28.7%]). Patients with HS had 4.51 [95% confidence interval, 4.40-4.63] times the odds of having AV than did patients without HS, with the higher likelihood of having AV persisting across all subgroups of patients with HS. The association between HS and AV was generally stronger for patients who were male, and 65 years of age or older.

Limitations

Influence of disease severity in HS, or in acne, on the strength of the association could not be assessed.

Conclusion

Patients with HS may benefit from assessment of acne status and optimization of comanagement strategies.

中文翻译：

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化脓性汗腺炎患者寻常痤疮的总体和亚组患病率

背景

确定寻常痤疮 (AV) 和化脓性汗腺炎 (HS) 之间联系的证据有限，且成人 HS 的 AV 负担尚不清楚。

客观的

确定 HS 成人中 AV 的患病率并确定这种关联的强度。

方法

通过使用来自超过 5500 万患者的基于人群样本的电子健康记录数据，横断面分析在患有和未患有 HS 的患者中识别出患有 AV 的成年人。

结果

HS 成人中 AV 的患病率为 15.2%（48,085 人中的 7315 人），而没有 HS 成人的 AV 患病率为 2.9%（16,899,470 人中的 497,360 人）（P  < .001）。HS 患者的患病率最高，女性（35,790 人中的 5870 人 [16.4%]）、18 至 44 岁（28,870 人中的 5260 人 [18.2%]）、非白人（17,825 人中的 3120 人 [17.5%]）、肥胖（35,135 人中的 5430 人 [15.5%]），并且患有多囊卵巢综合征（2385 人中的 685 人 [28.7%]）。HS 患者发生 AV 的几率是非 HS 患者的 4.51 [95% 置信区间，4.40-4.63] 倍，在所有 HS 患者亚组中持续存在 AV 的可能性更高。对于男性和 65 岁或以上的患者，HS 和 AV 之间的关联通常更强。

限制

无法评估 HS 或痤疮的疾病严重程度对关联强度的影响。

结论

HS 患者可能受益于痤疮状况的评估和共同管理策略的优化。