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Au-catalyzed intramolecular hydroalkoxylation of gem-difluorinated alkynols
Journal of Fluorine Chemistry ( IF 1.9 ) Pub Date : 2018-09-30 , DOI: 10.1016/j.jfluchem.2018.09.009
Jean-Denys Hamel , Jean-François Paquin

The intramolecular hydroalkoxylation of gem-difluorinated alkynols was found possible under Au catalysis, allowing for the preparation of a series of fluorinated heterocycles. The nature of the solvent was found to be especially critical in the cyclization of gem-difluorohomopropargylic alcohols as it dictated whether the resulting 2,3-dihydrofuran underwent subsequent aromatization to the corresponding furan or not.



中文翻译:

金的催化分子hydroalkoxylation宝石-difluorinated炔醇

发现在Au催化下,宝石-二氟化炔醇的分子内氢烷氧基化是可能的,从而允许制备一系列氟化杂环。发现溶剂的性质在宝石-二氟均丙炔醇的环化中特别关键,因为它决定了所得的2,3-二氢呋喃是否随后进行芳构化成相应的呋喃。

更新日期:2018-09-30
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