Optimization and application of the reported synthesis of (3-chloropyrazin-2-yl)methanamine 3 have provided a high yielding, fully telescoped procedure to key intermediate 5 in the synthesis of acalabrutinib.

中文翻译：

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Acalabrutinib合成中间体的生产工艺

所报道的（3-氯吡嗪-2-基）甲胺3的合成的优化和应用为acalabrutinib的合成中的关键中间体5提供了高产，完全可伸缩的方法。