The study was aimed at production of different organic acids (OA) (lactic, fumaric, or succinic) by various microbial cells (filamentous fungi Rhizopus oryzae (F-814, F-1127) and bacteria Actinobacillus succinogenes B-10111) immobilized into poly(vinyl alcohol) (PVA) cryogel from diverse renewable raw materials (wheat and rice straw, aspen and pine sawdust, Jerusalem artichoke stems and tubers, biomass of macro- and microalgae) under batch conditions. The process productivity, bulk output and OA concentrations were higher in case of using immobilized cells than in case of free cells under identical conditions. A higher OA productivity was reached via simultaneous enzymatic saccharification and microbial fermentation (SSF) of same raw materials as compared to their separate enzymatic hydrolysis and fermentation of accumulated reducing sugars (SHF). Maximal concentrations of all OAs studied were obtained for bioconversion of Jerusalem artichoke tubers. The immobilized cells were used in long-term conversion of various renewable materials to OAs in SSF.

该研究旨在通过各种微生物细胞（丝状真菌米根霉（F-814，F-1127）和细菌放线菌琥珀酸杆菌）生产不同的有机酸（乳酸，富马酸或琥珀酸）。在批处理条件下，将B-10111）从多种可再生原料（小麦和稻草，白杨和松木锯末，菊芋茎和块茎，大型藻类和微藻类生物质）固定化为聚乙烯醇（PVA）冷冻凝胶。在相同条件下，使用固定化细胞的过程生产率，批量产量和OA浓度要高于游离细胞。通过相同原料的同时酶促糖化和微生物发酵（SSF），与它们各自的酶促水解和累积的还原糖（SHF）发酵相比，可以实现更高的OA生产率。对于菊芋块茎的生物转化，获得了所研究的所有OA的最大浓度。固定的细胞用于将各种可再生材料长期转化为SSF中的OA。