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Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy
Biomaterials ( IF 14.0 ) Pub Date : 2018-09-28 , DOI: 10.1016/j.biomaterials.2018.09.041
Xingshu Li , C-yoon Kim , Jeong Min Shin , Dayoung Lee , Gyoungmi Kim , Hyung-Min Chung , Ki-Sung Hong , Juyoung Yoon

Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the “bystander effect.” Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.



中文翻译:

间充质干细胞驱动的可活化光敏剂,用于精密光动力肿瘤疗法

尽管仍存在挑战,但精确靶向且副作用最小的个性化医学尤其令人关注。在本文中,我们演示了利用人间充质干细胞(MSC)作为细胞载体来递送新的可激活光敏剂(PcS)的精密光动力疗法(PDT)。体内实时光学成像测试表明,装载PcS的MSC具有出色的肿瘤归巢特性。更重要的是,染料转移分析证实了MSC通过“旁观者效应”将PcS精确地转移到了人类结肠癌细胞(HCT116)中。在局部光照射下,光动力效应显着抑制了腹膜内异种移植肿瘤的生长。这些发现代表了精确肿瘤治疗的有前途的策略。

更新日期:2018-09-29
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