Palladium-catalyzed bond-forming reactions, such as the ­Suzuki–Miyaura and Mizoroki–Heck reactions, are some of the most broadly utilized reactions within the chemical industry. These reactions frequently employ hazardous solvents; however, to adhere to increasing sustainability pressures and restrictions regarding the use of such solvents, alternatives are highly sought after. Here we demonstrate the utility of dimethyl isosorbide (DMI) as a bio-derived solvent in several benchmark Pd-catalyzed reactions: Suzuki–Miyaura (13 examples, 62–100% yield), Mizoroki–Heck (13 examples, 47–91% yield), and Sonogashira (12 examples, 65–98% yield).

中文翻译：

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二甲基异山梨醇 (DMI) 作为 Pd 催化交叉偶联反应的生物衍生溶剂

钯催化的成键反应，例如 Suzuki-Miyaura 和 Mizoroki-Heck 反应，是化学工业中应用最广泛的反应之一。这些反应经常使用危险溶剂；然而，为了遵守有关使用此类溶剂的日益增加的可持续性压力和限制，人们迫切需要替代品。在这里，我们展示了二甲基异山梨醇 (DMI) 在几个基准 Pd 催化反应中作为生物衍生溶剂的效用：Suzuki-Miyaura（13 个例子，62-100% 产率），Mizoroki-Heck（13 个例子，47-91%）产率）和 Sonogashira（12 个例子，产率 65-98%）。