Nickel-catalysed alkylation of C(sp3)–H bonds with alcohols: direct access to functionalised N-heteroaromatics†,Chemical Communications

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Nickel-catalysed alkylation of C(sp3)–H bonds with alcohols: direct access to functionalised N-heteroaromatics†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-09-28 00:00:00 , DOI: 10.1039/c8cc06370b
Mari Vellakkaran _{1,

2,

3,

4,

5} , Jagadish Das _{1,

2,

3,

4,

5} , Sourajit Bera _{1,

2,

3,

4,

5} , Debasis Banerjee _{1,

2,

3,

4,

5}

Affiliation

The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr₂/L1 system enables access to a series of C(sp³)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.

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