In an attempt to further exploit multicomponent reactions in the field of hybrid heterocyclic molecules, we describe a bidirectional approach for the synthesis of novel 1,3,5-thiadiazine-peptides molecules. The process relies on the execution of two Ugi reactions between dicarboxy-functionalized 1,3,5-thiadiazine with different amines and isocyanides. An alternative strategy relying on a sequential multicomponent macrocyclization procedure was also developed to afford thiadiazine peptide-like macrocycles. Both methods showed great chemical efficiency and versatility.

中文翻译：

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通过双多组分反应双向获得新型噻二嗪杂化分子

为了进一步开发杂化杂环分子领域中的多组分反应，我们描述了一种合成新型1,3,5-噻二嗪-肽分子的双向方法。该方法依赖于在二羧基官能化的1,3,5-噻二嗪与不同的胺和异氰酸酯之间进行两次Ugi反应。还开发了一种依赖于顺序多组分大环化程序的替代策略，以提供噻二嗪肽样大环化合物。两种方法均显示出很高的化学效率和多功能性。