Deregulated cytokines' production is found in depressed patients. Salidroside and curcumin both have been described with potential antidepressant-like activities. The present study investigated the effect of pure salidroside, curcumin and their combination on the immunoreactivity of animals, subjected to a chronic mild stress (CMS) model, followed by lipopolysaccharide (LPS)-induced inflammation. Wistar male rats were separated in the following six groups: control, CMS model, fluoxetine (2.5 mg/kg, oral), salidroside (5 mg/kg, oral), curcumin (20 mg/kg, oral) and salidroside + curcumin (5 mg/kg + 20 mg/kg, oral). Changes in glucose preference, spatial learning and exploratory behavior were recorded. The IL-6 levels in the rats' sera and of the TNF-α levels in the rats' sera and the brain tissue homogenate were evaluated. The groups exposed to stress and treated with fluoxetine, salidroside, curcumin or salidroside + curcumin showed increase in the glucose preference and locomotor activity, as well as, decrease in the escape latency and the cytokines' levels compared to the CMS model group. The chronic stress induced behavioral alternations and increased cytokines’ levels in rats which were reversed by administration of salidroside and curcumin, suggesting antidepressant-like effects comparable to that of fluoxetine and potential synergistic interaction regarding the anti-inflammatory and anti-stress effects.

在抑郁症患者中发现细胞因子的产生失调。红景天苷和姜黄素都具有潜在的抗抑郁样活性。本研究调查了纯红景天苷，姜黄素及其组合对动物的免疫反应性的影响，该动物经受了慢性轻度应激（CMS）模型，然后是脂多糖（LPS）诱导的炎症。将Wistar雄性大鼠分为以下六组：对照组，CMS模型，氟西汀（2.5 mg / kg，口服），红景天苷（5 mg / kg，口服），姜黄素（20 mg / kg，口服）和红景天苷+姜黄素（ 5 mg / kg + 20 mg / kg，口服）。记录了葡萄糖偏好，空间学习和探索行为的变化。评价了大鼠血清中的IL-6水平以及大鼠血清和脑组织匀浆中的TNF-α水平。与CMS模型组相比，受到压力并用氟西汀，红景天苷，姜黄素或红景天苷+姜黄素治疗的组显示出葡萄糖偏爱和运动活性的增加，以及逃避潜伏期和细胞因子水平的降低。慢性应激引起大鼠行为改变和细胞因子水平升高，这可通过给予红景天苷和姜黄素来逆转，这表明与氟西汀类似的抗抑郁样作用以及潜在的协同相互作用在抗炎和抗应激作用方面具有潜在的协同作用。水平与CMS模型组进行比较。慢性应激引起大鼠行为改变和细胞因子水平升高，这可通过给予红景天苷和姜黄素来逆转，这表明与氟西汀类似的抗抑郁样作用以及潜在的协同相互作用在抗炎和抗应激作用方面具有潜在的协同作用。水平与CMS模型组进行比较。慢性应激引起大鼠行为改变和细胞因子水平升高，这可通过给予红景天苷和姜黄素来逆转，这表明与氟西汀类似的抗抑郁样作用以及潜在的协同相互作用在抗炎和抗应激作用方面具有潜在的协同作用。