A number of commercially-available chewing gums contain health-related ingredients including vitamins. The ability of chewing gum to deliver these ingredients to the plasma has not been well-studied. We examined the release and plasma levels of a panel of vitamins from two supplemented gums in 15 healthy human participants. We examined the release of vitamins from the gums into the saliva using a single-blind randomized design, and then determined the acute impact of chewing vitamin-supplemented gums on plasma vitamin concentrations in a single-blind, placebo-controlled, crossover study. Retinol, thiamine, riboflavin, niacinamide, pyridoxine, folic acid, cyanocobalamin, ascorbic acid, and α-tocopherol were released into the saliva by chewing. Plasma vitamin concentrations were increased for retinol (75–96%), pyridoxine (906–1077%), ascorbic acid (64–141%) and α-tocopherol (502–418%) after chewing the supplemented gums, compared to baseline. To our knowledge, this is the first study examining the delivery of vitamins using chewing gum in humans.

许多可商购的口香糖包含与健康有关的成分，包括维生素。口香糖将这些成分递送至血浆的能力尚未得到充分研究。我们在15位健康的人类参与者中检查了来自两种补充牙龈的一组维生素的释放和血浆水平。我们使用单盲随机设计检查了维生素从牙龈向唾液中的释放，然后在单盲，安慰剂对照，交叉研究中确定了补充维生素的口香糖对血浆维生素浓度的急性影响。通过咀嚼将视黄醇，硫胺素，核黄素，烟酰胺，吡ido醇，叶酸，氰钴胺，抗坏血酸和α-生育酚释放到唾液中。视黄醇（75–96％），吡ido醇（906–1077％）的血浆维生素浓度增加，与基线相比，咀嚼补充牙龈后的抗坏血酸（64–141％）和α-生育酚（502–418％）。据我们所知，这是第一项研究使用口香糖在人体中输送维生素的研究。