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Volume shrinkage of polypeptide hybrid xerogels induced by a helix-sense inversion
Polymer Journal ( IF 2.8 ) Pub Date : 2018-09-26 , DOI: 10.1038/s41428-018-0127-6
Yosuke Mizuno , Hidemine Furuya

AbstractPoly(l-aspartic acid β-ester) molecules (PAsp) are known for their unique temperature-dependent helix-sense inversion from right- to left-handed helices. This secondary structure transition is expected to switch their mechanical properties, which would allow the development of a stimuli-responsive, solid-state systems of biomaterials. In this work, PAsp hybrid xerogels (PAsp-xgs), which are polymethylmethacrylate xerogels crosslinked by PAsp, were synthesized, and the effects of the PAsp helix-sense inversion on their properties were investigated. PAsp-xg was found to irreversibly shrink to a volume ratio of 0.7 when heated to ~393 K. Notably, the PAsp moieties in the xerogels exhibited a helix-sense inversion at a similar temperature to that of the helix-sense inversion in the homopolymer. These results suggest that the helix-sense inversion induced the volume shrinkage of the PAsp-xgs. All in all, the PAsp-xg synthesized herein is expected to be a new, low environmental load material for stimulus-responsive systems.Poly(methyl methacrylate) smart xerogels (PAsp-xgs) crosslinked by polyaspartate side chains were synthesized and the effects of the polyaspartate helix-sense inversion on their properties were investigated. PAsp-xg was found to irreversibly shrink to a volume ratio of 0.7 when heated to ~393 K. The volume shrinkage was suggested to be induced by the helix-sense inversion of the polyaspartates in the hybrid xerogels.

中文翻译:

螺旋义反转诱导的多肽杂化干凝胶的体积收缩

摘要 聚(l-天冬氨酸 β-酯)分子 (PAsp) 以其独特的温度依赖性螺旋感从右手螺旋到左手螺旋的反转而闻名。这种二级结构转变有望改变它们的机械性能,这将有助于开发一种刺激响应的固态生物材料系统。在这项工作中,合成了 PAsp 杂化干凝胶 (PAsp-xgs),它是由 PAsp 交联的聚甲基丙烯酸甲酯干凝胶,并研究了 PAsp 螺旋义反转对其性质的影响。当加热到~393 K 时,发现 PAsp-xg 不可逆地收缩到 0.7 的体积比。 值得注意的是,干凝胶中的 PAsp 部分在与均聚物中的螺旋感应反转温度相似的温度下表现出螺旋感应反转. 这些结果表明螺旋义反转诱导了 PAsp-xgs 的体积收缩。总而言之,本文合成的 PAsp-xg 有望成为一种用于刺激响应系统的新型低环境负荷材料。 合成了由聚天冬氨酸侧链交联的聚(甲基丙烯酸甲酯)智能干凝胶(PAsp-xgs),并对其影响进行了研究。研究了聚天冬氨酸螺旋义反转对其性质的影响。当加热到~393 K 时,发现 PAsp-xg 不可逆地收缩到 0.7 的体积比。体积收缩被认为是由混合干凝胶中聚天冬氨酸的螺旋感反转引起的。合成了由聚天冬氨酸侧链交联的聚(甲基丙烯酸甲酯)智能干凝胶(PAsp-xgs),并研究了聚天冬氨酸螺旋义反转对其性能的影响。当加热到~393 K 时,发现 PAsp-xg 不可逆地收缩到 0.7 的体积比。体积收缩被认为是由混合干凝胶中聚天冬氨酸的螺旋感反转引起的。合成了由聚天冬氨酸侧链交联的聚(甲基丙烯酸甲酯)智能干凝胶(PAsp-xgs),并研究了聚天冬氨酸螺旋义反转对其性能的影响。当加热到~393 K 时,发现 PAsp-xg 不可逆地收缩到 0.7 的体积比。体积收缩被认为是由混合干凝胶中聚天冬氨酸的螺旋感反转引起的。
更新日期:2018-09-26
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