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1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-09-26 00:00:00 , DOI: 10.1039/c8cc07328g
Renjie Chen 1, 2, 3 , Yu Liu 2, 4, 5 , Sunliang Cui 1, 2, 3
Affiliation  

A novel 1,4-conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction has been developed. In this protocol, numerous carboxylic acids, ynamides and in situ generated ortho-quinone methides could assemble rapidly to constitute this process for the synthesis of functionalized 3,3-diarylpropanamides with sufficient structural diversity. Furthermore, the products could be transformed to an array of compounds.

中文翻译:

在多组分反应中 1,4-共轭甲醌甲基化物的加成/酯化反应

的新的1,4-共轭加成/酯化-quinone的甲基化物中的多组分反应已经研制成功。在该方案中,许多羧酸,乙酰胺和原位生成的醌甲基化物可以迅速组装,从而构成用于合成具有足够结构多样性的官能化3,3-二芳基丙酰胺的过程。此外,可以将产物转化为一系列化合物。
更新日期:2018-09-26
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