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Polyethyleneimine methylenecarboxylate: a macromolecular DTPA analogue to chelate plutonium(iv)†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-09-25 00:00:00 , DOI: 10.1039/c8cc05206a
Florian Lahrouch 1, 2, 3, 4, 5 , Bruno Siberchicot 6, 7, 8, 9, 10 , Laurane Leost 1, 2, 3, 4, 5 , Jean Aupiais 6, 7, 8, 9, 10 , André Rossberg 11, 12, 13, 14 , Christoph Hennig 11, 12, 13, 14 , Christophe Den Auwer 1, 2, 3, 4, 5 , Christophe Di Giorgio 1, 2, 3, 4, 5
Affiliation  

Up until now, molecular chelating agents, such as diethylenetriamine pentaacetic acid (DTPA), have been the standard method for actinide human decorporation. Mainly active in blood serum, their distribution within the body is thus limited. To treat a wider range of organs affected by plutonium contamination, a potential new class of macromolecular decorporation agents is being studied. Polyethyleneimine methylenecarboxylate (PEI-MC) is one such example. It is being considered here because of its capacity for targeting the liver and bones.

中文翻译:

聚乙烯亚胺亚甲基羧酸酯:螯合p(iv)的大分子DTPA类似物

到目前为止,分子螯合剂,例如二亚乙基三胺五乙酸(DTPA),一直是act系元素人类脱附的标准方法。它们主要在血清中起作用,因此它们在体内的分布受到限制。为了治疗受p污染影响的更广泛的器官,正在研究潜在的新型大分子分解剂。聚乙烯亚胺亚甲基羧酸酯(PEI-MC)就是这样的一个例子。由于它具有靶向肝脏和骨骼的能力,因此在这里被考虑。
更新日期:2018-09-25
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