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Theranostics based on AIEgens
Theranostics ( IF 12.4 ) Pub Date : 2018-09-09 , DOI: 10.7150/thno.27787
Dong Wang 1, 2 , Michelle Mei Suet Lee 2 , Wenhan Xu 2 , Ryan Tsz Kin Kwok 2 , Jacky Wing Yip Lam 2 , Ben Zhong Tang 1, 2
Affiliation  

The utilization of luminogens with aggregation-induced emission (AIE) characteristics has recently been developed at a tremendous pace in the area of theranostics, mainly because AIE luminogens (AIEgens) hold various distinct advantages, such as good biocompatibility, excellent fluorescence properties, simple preparation and modification, perfect size of nano-aggregation for enhanced permeability and retention effect, promoted efficiencies of photodynamic and photothermal therapies, efficient photoacoustic imaging, and ready constructions of multimodal imaging and therapy. Significant breakthroughs and developments of theranostics based on AIEgens have been achieved in the past few years, and great progress has been witnessed in many theranostic modalities, indicating that AIEgens remarkably complement conventional theranostic materials and promote the development of theranostics. This review provides theoretical insights into the advantages of AIEgens in theranostics, and systematically summarizes the basic concepts, seminal studies, recent trends and perspectives in theranostics based on AIEgens. We believe that AIEgens would be promising multifunctional theranostic platforms in clinical fields and facilitate significant advancements in this research-active area.

Keywords: AIEgens, fluorescence imaging, photoacoustic imaging, cancer therapy, antibiosis



中文翻译:

基于 AIEgens 的治疗诊断学

具有聚集诱导发射(AIE)特性的发光剂的应用近年来在治疗诊断领域得到了飞速发展,这主要是因为AIE发光剂(AIEgens)具有多种独特的优点,如良好的生物相容性、优异的荧光性能、制备简单等。和修饰,完美尺寸的纳米聚集体可增强渗透性和保留效果,提高光动力和光热疗法的效率,高效的光声成像,以及多模态成像和治疗的现成结构。基于AIEgens的治疗诊断学在过去几年中取得了重大突破和发展,许多治疗诊断模式都取得了巨大进展,这表明AIEgens对传统治疗诊断材料起到了显着的补充作用,促进了治疗诊断学的发展。本文对AIEgens在治疗诊断学中的优势提供了理论见解,并系统总结了基于AIEgens的治疗诊断学的基本概念、开创性研究、最新趋势和观点。我们相信 AIEgens 将成为临床领域有前景的多功能治疗诊断平台,并促进这一研究活跃领域的重大进展。

关键词:AIEgens,荧光成像,光声成像,癌症治疗,抗生素

更新日期:2018-09-25
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