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Fusarium mycotoxins and in vitro species-specific approach with porcine intestinal and brain in vitro barriers: A review
Food and Chemical Toxicology ( IF 4.3 ) Pub Date : 2018-09-22 , DOI: 10.1016/j.fct.2018.09.050
A. Bertero , L.J. Spicer , F. Caloni

Fusarium mycotoxins, such as fumonisins, trichothecenes, zearalenone and emerging fusariotoxins, common contaminants of feed and food, have received increased interest, due to the possible impact on animal and human health.

In this context, it is urgent to focus our attention on fusariotoxins adverse effects, considering and analysing data in relation to their species-specificity.

The in vitro approach for fusariotoxins risk assessment evaluation, through porcine epithelial barriers model, allowed to collect information on their absorption profile, bioavailability and toxicity.

The aim of this review is to give an overview on Fusarium mycotoxins and their interactions with porcine intestinal and brain in vitro barriers, because they represent direct target organs of toxicity and as tools to evaluate their permeability and transport.



中文翻译:

镰刀菌真菌毒素和猪肠道和脑体外屏障的体外物种特异性方法:综述

由于对动物和人类健康的可能影响,镰刀菌真菌毒素,如伏马毒素,曲霉烯,玉米赤霉烯酮和新兴的富沙里毒素,饲料和食品的常见污染物,已引起人们越来越多的关注。

在这种情况下,迫切需要将我们的注意力集中在镰刀菌毒素的不利影响上,考虑和分析与它们的物种特异性有关的数据。

体外对fusariotoxins风险评估评价办法,通过猪的上皮屏障模型,允许在他们的吸收情况,生物利用度和毒性收集信息。

这篇综述的目的是概述镰刀菌真菌毒素及其与猪肠道和脑体外屏障的相互作用,因为它们代表了毒性的直接靶器官,并且是评估其通透性和转运的工具。

更新日期:2018-09-22
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