Chiral-diamine catalyzed addition of ZnMe₂ to PhC(O)CF₂X (in dichloromethane at −30 °C) affords fluorinated alkyl tertiary alcohols in high yield (quantitative for X = H, F, Cl; 84% for X = CF₃) and up to 99% ee. These conditions are similarly very efficient for other various ArC(O)CF₃ molecules. A fine analysis of the results can be performed based on a double-cycle mechanism.

中文翻译：

---

将二甲基锌高度对映选择性地添加到氟化烷基酮中，以及其背后的机理†

将手性二胺催化的ZnMe ₂加到PhC（O）CF ₂ X中（在-30°C的二氯甲烷中），可以得到高产率的氟化烷基叔醇（X = H，F，Cl定量； X = CF的定量为84％）₃）和高达99％的ee。这些条件对于其他各种ArC（O）CF ₃分子同样非常有效。可以基于双循环机制对结果进行精细分析。