Our present study investigates the immune enhancing effects of JW15 on cyclophosphamide (CPM)-induced immunosuppression in BALB/c mice. In our previous study, we demonstrated the immune enhancing effects of Weissella cibaria JW15 (JW15) isolated from Kimchi (Korean traditional fermented vegetables) on macrophage cells and Listeria monocytogenes challenge model. The recovery levels of white blood cells and the mean spleen weight per body weight (g/kg) of JW15-treated group was significantly larger than that of the CPM-treated group. Moreover, JW15 administration enhanced the recovery of splenocyte proliferation in CPM-treated mice. In addition, JW15 supplementation stimulated the production of cytokines (TNF- α and IL-6) in splenocytes. Thus, JW15 could promote the ability from CPM-induced immunosuppression. In conclusion, W. cibaria JW15 exhibits the ability to induce immune-enhancing effects and could be a suitable functional food additive for humans and companion animals.

我们目前的研究调查JW15对BALB / c小鼠中环磷酰胺（CPM）诱导的免疫抑制的免疫增强作用。在我们先前的研究中，我们证明了从泡菜（韩国传统发酵蔬菜）中分离的魏氏菌Weissella cibaria JW15（JW15）对巨噬细胞和单核细胞增生李斯特菌的免疫增强作用挑战模型。JW15治疗组白细胞的恢复水平和平均脾脏平均体重（g / kg）显着大于CPM治疗组。此外，JW15给药增强了CPM处理的小鼠脾细胞增殖的恢复。另外，补充JW15刺激了脾细胞中细胞因子（TNF-α和IL-6）的产生。因此，JW15可以促进CPM诱导的免疫抑制能力。总之，W。cibaria JW15具有诱导免疫增强作用的能力，并且可能是适用于人类和伴侣动物的功能性食品添加剂。