当前位置: X-MOL 学术Food Chem. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies
Food and Chemical Toxicology ( IF 4.3 ) Pub Date : 2018-09-21 , DOI: 10.1016/j.fct.2018.09.039
Sonia Marín , German Cano-Sancho , Vicente Sanchis , Antonio J. Ramos

Mycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental insults threating human health throughout the entire lifespan. Given the large potential impact of mycotoxins in terms of human exposure and related health effects, the ambition of this review is to present this group of chemical compounds and the high interest to be included in exposome projects. Furthermore, we also attempt to approach the novel exposome paradigm to more traditional disciplines such as mycotoxin exposure assessment and mycotoxicology, introducing the new methodological challenges and translational needs. Hence, we provide an overview of major biomarkers currently developed, biological matrices where these may be found, an overview of internal exposure levels and potential co-occurrence with environmental chemicals and finally an overview of major health effects with the illustrative example of the potent xenoestrogen zearalenol. Conversely, these new approaches may be an excellent opportunity to fill many research gaps on mycotoxins research as the identification of associations with human health, elucidation of join effect with other environmental exposures or the decipher of underlying molecular mechanisms by using advanced OMICs technologies.



中文翻译:

霉菌毒素在人类暴露小体中的作用:真菌毒素生物标志物在暴露小体健康研究中的应用

霉菌毒素是由真菌产生的次生代谢产物,可能污染打算供人类食用的不同食物,从而导致全世界范围内的广泛接触。新颖的暴露范式旨在消除在整个生命周期中威胁人类健康的各种环境侮辱。鉴于霉菌毒素对人体暴露和相关健康影响的巨大潜在影响,本综述的目的是介绍这一类化合物,并将其高度关注纳入暴露项目中。此外,我们还尝试将新颖的暴露范式应用于更传统的学科,例如霉菌毒素暴露评估和霉菌毒理学,引入新的方法论挑战和转化需求。因此,我们概述了当前开发的主要生物标志物,可能发现这些物质的生物基质,内部暴露水平的概述以及与环境化学品的潜在共存,最后概述了主要的健康影响,并举例说明了强力异种雌激素玉米赤霉烯醇。相反,这些新方法可能是填补霉菌毒素研究中许多研究空白的绝好机会,因为它们可以鉴定与人类健康的关联,阐明与其他环境暴露的结合效应或通过使用先进的OMIC技术来破译潜在的分子机制。

更新日期:2018-09-21
down
wechat
bug