A colorimetric naked-eye chemosensor for histidine (His) was established by mixing a thiazolylazo dye and Ni²⁺ in a 1:1 M ratio (TAMSMB-Ni²⁺). Due to the interaction of Ni²⁺ with His, TAMSMB was regenerated upon the addition of His to TAMSMB-Ni²⁺ to lead a significant hypsochromic shift in absorption spectra accompanied by a visual color change from red to yellow which can be directly observed by the naked eye. On the other hands, other amino acids did not trigger any significant changes in absorption properties and solution color. Moreover, it exhibited the selective recognition of His without obvious interference from other amino acids. Thus, TAMSMB-Ni²⁺ can act as a simple and efficient colorimetric chemosensor for His with sensitivity and selectivity in aqueous solution.

通过将噻唑基偶氮染料和Ni ²⁺以1：1 M的比例混合（TAMSMB-Ni ²⁺），建立了用于组氨酸（His）的比色肉眼化学传感器。由于Ni ²⁺与His的相互作用，将TAMSMB-Ni ²⁺加入His后，TAMSMB得以再生，从而导致吸收光谱发生显着的变色，并伴有可见的从红色到黄色的颜色变化，可通过观察直接观察到。肉眼。另一方面，其他氨基酸没有引起吸收特性和溶液颜色的任何显着变化。此外，它显示出对His的选择性识别，而不受其他氨基酸的明显干扰。因此，TAMSMB-Ni ²⁺ 可以作为His的简单高效的比色化学传感器，在水溶液中具有灵敏度和选择性。