Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl. Herein, we optimized the admixture vaccine and found that it surpassed the individual vaccines in every antinociceptive test, including a 10% fentanyl to heroin formulation. It is anticipated that other co-occurring drug abuse disorders may also be examined with admixture vaccines.

中文翻译：

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芬太尼和海洛因半抗原免疫偶联物的改良混合疫苗：受芬太尼污染的海洛因的抗伤害感受性评估

芬太尼及其衍生物已成为美国海洛因供应中的普遍污染物。此前，我们报道了一种概念证明疫苗，旨在对抗被芬太尼污染的海洛因。在本文中，我们优化了混合疫苗，并发现它在每个抗伤害感受试验中都超过了单独的疫苗，其中包括10％的芬太尼对海洛因的制剂。预期也可以用混合疫苗检查其他同时发生的药物滥用疾病。