Series of half-sandwich Ir^III N-heterocyclic carbene (NHC) antitumor complexes [(η⁵-Cp*)Ir(C^C)Cl] have been synthesized and characterized (Cp* is pentamethyl cyclopentadienyl, and C^C are four NHC chelating ligands containing phenyl rings at different positions). Ir^III complexes showed potent antitumor activity with IC₅₀ values ranged from 3.9 to 11.8 μM against A549 cells by the MTT assay. Complexes can catalyze the conversion of the coenzyme NADH to NAD⁺ and induce the production of reactive oxygen species (ROS), and bonding to BSA by static quenching mode. Complexes can arrest the cell cycle in G₁ or S phase and reduce the mitochondrial membrane potential. Confocal microscopy test show complexes could target the lysosome and mitochondria in cells with the Pearson's colocalization coefficient of 0.82 and 0.21 after 12 h, respectively, and followed by an energy-dependent cellular uptake mechanism.

半夹心的Ir系列^III ñ -杂环卡宾（NHC）的抗肿瘤复合物[（η ⁵ -Cp *）IR（C ^ C）CL]已被合成和表征（CP *是五甲基环戊二烯基，和C ^ C四种在不同位置含有苯环的NHC螯合配体）。Ir ^Mt复合物显示出有效的抗肿瘤活性，通过MTT分析，其对A549细胞的IC ₅₀值范围为3.9至11.8μM。复合物可以催化辅酶NADH向NAD ⁺的转化，并诱导产生活性氧（ROS），并通过静态猝灭模式与BSA结合。复合物可以阻止G _1中的细胞周期或S相并降低线粒体膜电位。共聚焦显微镜测试显示，复合物可靶向细胞中的溶酶体和线粒体，Pearson的共定位系数分别为12 h后为0.82和0.21，然后是能量依赖的细胞摄取机制。