Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations,PLOS ONE

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Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations
PLOS ONE ( IF 3.7 ) Pub Date : 2018-09-20 , DOI: 10.1371/journal.pone.0204459
Hiroshi Furukawa , Shomi Oka , Kota Shimada , Atsushi Hashimoto , Akiko Komiya , Shinichiro Tsunoda , Akiko Suda , Satoshi Ito , Koichiro Saisho , Masao Katayama , Satoshi Shinohara , Takeo Sato , Katsuya Nagatani , Seiji Minota , Toshihiro Matsui , Naoshi Fukui , Shoji Sugii , Hajime Sano , Kiyoshi Migita , Shouhei Nagaoka , Shigeto Tohma

Objective

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations.

Methods

Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls.

Results

In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16–1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (P_adjusted = 0.0003, Pc_adjusted = 0.0040, OR_adjusted 1.47, 95%CI 1.19–1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (P_adjusted = 0.0091, Pc_adjusted = 0.1184, OR_adjusted 0.78, 95%CI 0.65–0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected.

Conclusion

The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.

中文翻译：

独立协会HLA-DPB1 * 02：01在日本人群类风湿性关节炎

客观的

类风湿关节炎（RA）是一种慢性自身免疫性疾病，其特征在于关节破坏；认为环境和遗传因素与RA的病因有关。抗瓜氨酸肽抗体（ACPA）的产生与RA特异性相关。DRB1与RA的敏感性有关，尤其是ACPA阳性RA [ACPA（+）RA]。但是，一些研究报道了DPB1等位基因与RA易感性的独立关联。因此，我们调查了日本人群中DPB1等位基因与RA的独立关联。

方法

通过Logistic回归分析对1667名RA患者和413名对照进行DPB1关联分析。

结果

在未调节的分析，DPB1 * 04：02名义上与ACPA（+）RA（易感性相关P = 0.0021，校正P（PC）= 0.0275，OR为1.52，95％置信区间[CI] 1.16- 1.99）。的显著关联DPB1 * 02：01，观察到与ACPA（+）RA的易感性，对空调时DRB1（P_调整= 0.0003，P c ^_调整= 0.0040，OR_调整1.47，95％CI 1.19-1.81）。DPB1 * 05：01当以DRB1为条件时，通常倾向于与针对ACPA（+）RA的保护相关（P_调整= 0.0091，P c_调整= 0.1184，OR_调整0.78，95 ％CI 0.65-0.94）。当空调DRB1，协会DPB1 * 04：02与ACPA（+）RA反应消失。无关联DPB1检测与ACPA阴性RA等位基因。