当前位置: X-MOL 学术Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A Neural Circuit for Gut-Induced Reward.
Cell ( IF 64.5 ) Pub Date : 2018-Oct-18 , DOI: 10.1016/j.cell.2018.08.049
Wenfei Han , Luis A. Tellez , Matthew H. Perkins , Isaac O. Perez , Taoran Qu , Jozelia Ferreira , Tatiana L. Ferreira , Daniele Quinn , Zhong-Wu Liu , Xiao-Bing Gao , Melanie M. Kaelberer , Diego V. Bohórquez , Sara J. Shammah-Lagnado , Guillaume de Lartigue , Ivan E. de Araujo

The gut is now recognized as a major regulator of motivational and emotional states. However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical activation of gut-innervating vagal sensory neurons recapitulates the hallmark effects of stimulating brain reward neurons. Specifically, right, but not left, vagal sensory ganglion activation sustained self-stimulation behavior, conditioned both flavor and place preferences, and induced dopamine release from Substantia nigra. Cell-specific transneuronal tracing revealed asymmetric ascending pathways of vagal origin throughout the CNS. In particular, transneuronal labeling identified the glutamatergic neurons of the dorsolateral parabrachial region as the obligatory relay linking the right vagal sensory ganglion to dopamine cells in Substantia nigra. Consistently, optical activation of parabrachio-nigral projections replicated the rewarding effects of right vagus excitation. Our findings establish the vagal gut-to-brain axis as an integral component of the neuronal reward pathway. They also suggest novel vagal stimulation approaches to affective disorders.

中文翻译:

肠道诱导奖赏的神经回路。

如今,肠道被认为是激励和情绪状态的主要调节者。然而,相关的肠脑神经元电路仍然未知。我们表明肠道激活迷走神经感觉神经元的光学激活概括了刺激大脑奖励神经元的标志性作用。具体来说,迷走神经感觉神经节激活的右侧但不是左侧,持续了自我刺激行为,调节了口味和位置偏好,并诱导了黑质释放多巴胺。细胞特异性跨神经元示踪显示整个CNS中迷走神经起源的不对称上升途径。特别地,经神经元标记将臂外侧臂旁区的谷氨酸能神经元鉴定为将右迷走感觉神经节与黑质中的多巴胺细胞连接的强制性中继。始终如一 臂旁神经投射的光学激活复制了右迷走神经兴奋的奖励作用。我们的发现将迷走性肠脑轴确立为神经元奖励途径的组成部分。他们还提出了新颖的迷走神经刺激方法来治疗情感障碍。
更新日期:2018-09-20
down
wechat
bug